Modified IAI 00843 - 07 Version 2 1 2 A recombinant Holo - toxoid Vaccine against Botulism 3 4
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چکیده
Modified IAI00843-07 Version2 1 2 A recombinant Holo-toxoid Vaccine against Botulism 3 4 Christina L. Pier, William H. Tepp, Marite Bradshaw, Eric A. Johnson, Joseph 5 T. Barbieri, and Michael R. Baldwin*. 6 7 Food Research Institute, University of Wisconsin, Madison, Wisconsin and 8 Department of Microbiology and Molecular Genetics, Medical College of 9 Wisconsin, Milwaukee, Wisconsin. 10 11 *Address correspondence to: 12 Michael R. Baldwin, PhD 13 Medical College of Wisconsin 14 8701 Watertown Plank Road 15 Milwaukee, WI 53226 16 Phone (414)456-8419; Fax (414)456-6535; Email [email protected] 17 18 Short title: A Holo-toxoid Vaccine against Botulism 19
منابع مشابه
Enhancing the protective immune response against botulism.
The need for a vaccine against botulism has increased since the discontinuation of the pentavalent (ABCDE) botulinum toxoid vaccine by the Centers for Disease Control and Prevention. The botulinum toxins (BoNTs) are the primary virulence factors and vaccine components against botulism. BoNTs comprise three domains which are involved in catalysis (LC), translocation (HCT), and host receptor bind...
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Botulinum neurotoxins (BoNT) cause the flaccid paralysis of botulism by inhibiting the release of acetylcholine from motor neurons. There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was used to vaccinate people who are at high risk of contracting botulism. Howe...
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The botulinum neurotoxins (BoNT) are the most toxic proteins for humans and designated "Category A Select Agents." The current vaccine against botulism is in limited supply, and there is a need to develop new vaccine strategies. A recombinant BoNT/A toxoid was produced in Clostridium botulinum that contained a double amino acid substitution, R363A Y365F (termed BoNT/A(RYM)). BoNT/A(RYM) was non...
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Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis. The BoNTs C and D are the main serotypes responsible for botulism in animals, including buffaloes. Botulism is one of the leading causes of death in adult ruminants in Brazil due to the high mortality rates, even though botulism in ...
متن کاملThe effect of pH on recombinant C-terminal domain of Botulinum Neurotoxin type E (rBoNT/E-HCC)
Recombinant proteins are tending to be the most favorable vaccine-candidates against botulism. Recombinant Carboxy-terminal of botulinum neurotoxin serotype E (rBoNT/E-HCC) has been introduced as an efficient vaccine against botulism type E. In this report, we made an effort to investigate the effect of different pH on protein structure to assess if rBoNT/E-HCC could be used as a vaccine for or...
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